speE [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]

spermidine synthase

locus: BSU37500

pI: 5.00

mw: 31.00 kDa

function: spermidine, polyamine biosynthesis

product: spermidine synthase

essential: no

ec: 2.5.1.16

synonyms: ywhF

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.6|Metabolism of polyamines]

[SW|Categories] containing this gene/protein

• [SW|miscellaneous metabolic pathways], [SW|sporulation/ other]

Gene

Coordinates on the chromosome (coding sequence): 3,848,786 -> 3,849,616

Phenotypes of a mutant

• inactivation of ''[SW|speE]'' reduces [SW|sporulation] efficiency to 6% that of wild type cells; delayed entry into [SW|sporulation] [Pubmed|26735940]

The protein

Catalyzed reaction/ biological activity

• S-adenosylmethioninamine putrescine = 5'-S-methyl-5'-thioadenosine spermidine (according to Swiss-Prot)

Protein family

• spermidine/spermine synthase family (according to Swiss-Prot)

Structure

• [PDB|1IY9]

Expression and Regulation

Operon

• ''[protein|search|speE]-[protein|search|speB]'' [Pubmed|9723923]
• ''[protein|search|speE]'' [Pubmed|9723923]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|9723923]

Biological materials

Mutant

• BKE37500 (''[protein|search|speE]''::''erm'', available in the BGSC and in [SW|Jörg Stülke]'s lab)

References

• 9723923,26735940