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maeA [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]
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maeA [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]

malic enzyme
locus
BSU37050
pI
4.88
mw
63.00 kDa
function
malate utilization
product
NAD-dependent malate dehydrogenase
essential
no
ec
1.1.1.38
synonyms
ywkA

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.1|Utilization of organic acids]
  • [SW|Categories] containing this gene/protein

  • [SW|utilization of specific carbon sources]
  • This gene is a member of the following [SW|regulons]

  • [SW|MalR regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,800,418 -> 3,802,166

    The protein

    Catalyzed reaction/ biological activity

  • (S)-malate + NAD+ = pyruvate + CO2 + NADH (according to Swiss-Prot) malate --> pyruvate
  • Protein family

  • malic enzymes family (according to Swiss-Prot)
  • Paralogous protein(s)

  • [protein|search|MalS]
  • Expression and Regulation

    Operon

  • ''[protein|search|maeA]-[protein|search|ywkB]'' [Pubmed|12949160]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|12949160]
  • Regulation

  • expressed in the presence of malate ([protein|search|MalR]) [Pubmed|12949160]
  • Regulatory mechanism

  • [protein|search|MalR]: transcription activation [Pubmed|12949160]
  • Additional information

  • the mRNA is substantially stabilized upon depletion of [Rny|search|RNase Y] [PubMed|21815947]
  • Biological materials

    Mutant

  • GP1141 (aphA3) available in [SW|Stülke] lab
  • Labs working on this gene/protein

  • [SW|Stephane Aymerich], Microbiology and Molecular Genetics, INRA Paris-Grignon, France
  • References

  • 21815947,23136871,12949160,16788182