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ftsH [2017-8-11 16:0:3]
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ftsH [2017-8-11 16:0:3]

ATP-dependent metalloprotease
Locus
BSU00690
Isoelectric point
5.84
Molecular weight
70.76 kDa
Protein length
637 aa Sequence Blast
Gene length
1911 bp Sequence Blast
Function
cell division, sporulation initiation
Product
ATP-dependent metalloprotease
Essential
no
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Cellular processes → Cell envelope and cell division → Cell division → Other genes
  • Information processing → Protein synthesis, modification and degradation → Proteolysis → Additional proteins involved in proteolysis
  • Lifestyles → Exponential and early post-exponential lifestyles → Biofilm formation
  • Lifestyles → Exponential and early post-exponential lifestyles → Biofilm formation → Regulation
  • Lifestyles → Coping with stress → Cell envelope stress proteins (controlled by SigM, V, W, X, Y)
  • Lifestyles → Coping with stress → Heat shock proteins
  • Groups of genes → Membrane proteins

    • Gene

    Coordinates
    76,984 → 78,897

    Phenotypes of a mutant

  • defective in biofilm formation PubMed
  • strongly reduced sporulation frequency PubMed, PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • degrades Spo0E and Spo0M, resulting in reduced sporulation frequency in a ftsH mutant PubMed
  • FtsH is involved in the degradation of EzrA PubMed
  • degrades SpoIIE PubMed

    • Paralogous protein(s)

  • YjoB

    • Effectors of protein activity

  • protease activity is controlled by the interaction with the flottilins FloA and FloT PubMed

    • Structure

  • 1LV7 (from E. coli, 64% identity) PubMed

    • Localization

  • cell membrane PubMed
  • preferentially at the division septum PubMed
  • forms some foci in the membrane PubMed

    • Expression and Regulation

    Operons

    Genes
    tilS-hprT-ftsH
    Description
    PubMed

    Sigma factors

  • SigM: sigma factor, PubMed, in SigM regulon
  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • TilS: activation, with HprT PubMed, in TilS regulon
  • HprT: activation, with TilS PubMed, in HprT regulon

    • Regulation

  • induced by heat shock (class III)

    • Additional information

  • the mRNA is very stable (half-life > 15 min) PubMed
    • view in new tab

    Genes
    spoIIE-yabS-yabT-tilS-hprT-ftsH
    Description
    PubMed

    Sigma factors

  • SigF: sigma factor, PubMed, in SigF regulon

    • Regulation

  • expressed early during sporulation in the forespore (SigF) PubMed
    • view in new tab

    Genes
    ftsH
    Description
    PubMed

    Regulation

  • induced by heat shock (class III)

    • Additional information

  • the mRNA is very stable (half-life > 15 min) PubMed
    • view in new tab

    Biological materials

    Mutant

  • MGNA-A084 (ftsH::erm), available at the NBRP B. subtilis, Japan
  • 1A1061 ( ftsH::cat), PubMed, available at BGSC
  • 1A1060 ( ftsH::erm), PubMed, available at BGSC

    • References

    Reviews

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    Original publications

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