trxA [2019-10-30 11:18:42]

thioredoxin, antioxidative action by facilitating the reduction of other proteins by cysteine thiol-disulfide exchange, important for the prevention of protein aggregation during severe heat stress

Locus: BSU_28500

Isoelectric point: 4.31

Molecular weight: 11.25 kDa

Protein length: 104 aa

Gene length: 315 bp

Function: protection of proteins against oxidative damage

Product: thioredoxin

Essential: yes

Synonyms: trx

Genomic Context

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Categories containing this gene/protein

• Metabolism → Electron transport and ATP synthesis → Electron transport/ other
• Lifestyles → Coping with stress → General stress proteins (controlled by SigB)
• Lifestyles → Coping with stress → Resistance against oxidative and electrophile stress
• Groups of genes → Essential genes

Gene

Coordinates: 2,913,024 2,913,338

Phenotypes of a mutant

• essential PubMed

The protein

Protein family

• Thioredoxin family (according to UniProt)

Paralogous protein(s)

• YdbP, YosR

Domains

• Thioredoxin domain (aa 2-104) (according to UniProt)

Structure

• 2GZZ (oxidized form), 2GZY (reduced form), 2IPA (TrxA-ArsC-complex) PubMed

Localization

• cytoplasm PubMed

Expression and Regulation

Operons

• Genes: trxA
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • SigB: sigma factor, PubMed, in SigB regulon

  Regulatory mechanism

  • CtsR: repression, PubMed, in CtsR regulon
  • Spx: activation, PubMed, in Spx regulon

  Regulation

  • induced by heat stress (CtsR) PubMed

  Additional information

  • induced by cell wall stress (Spx) PubMed
  • A ncRNA is predicted between TrxA and Abf2 PubMed

References

Reviews

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Original publications

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