SubtiBank SubtiBank
skfC [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

skfC [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]

may be involved in spore killing
locus
BSU01935
pI
8.00
mw
56.00 kDa
function
may be involved in spore killing
product
unknown
essential
no
synonyms
ybcS
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins]
  • [category|SW 5|Prophages and mobile genetic elements] → [category|SW 5.1|Prophages] → [category|SW 5.1.4|Prophage 1]

    • [SW|Categories] containing this gene/protein

  • [SW|toxins, antitoxins and immunity against toxins], [SW|prophage 1]

    • This gene is a member of the following [SW|regulons]

  • [SW|AbrB regulon], [SW|PhoP regulon], [SW|Spo0A regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    215,404 -> 216,894

    Expression and Regulation

    Operon

  • ''[protein|search|skfA]-[protein|search|skfB]-[protein|search|skfC]-[protein|search|skfE]-[protein|search|skfF]-[protein|search|skfG]-[protein|search|skfH]'' [Pubmed|16816204]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|16452424]

    • Regulation

  • expressed under conditions that trigger sporulation ([SW|Spo0A]) [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647,15687200 PubMed]
  • repressed during logrithmic growth ([protein|search|AbrB]) [http://www.ncbi.nlm.nih.gov/sites/entrez/15687200,17720793 PubMed]
  • induced by phosphate starvation ([protein|search|PhoP]) [Pubmed|16816204]
  • expression during spore [SW|germination] is strongly reduced under conditions of osmotic stress [Pubmed|27766092]

    • Regulatory mechanism

  • [SW|Spo0A]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647,15687200 PubMed]
  • [protein|search|AbrB]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/15687200,17720793 PubMed]
  • [protein|search|PhoP]: transcription activation [Pubmed|16816204]

    • Additional information

  • Northern blotting during during phosphate limitation showed an intense 0.25 kb '[protein|search|skfA]'-specific transcript, and a weaker 6.5 kb '[protein|search|skfA]-[protein|search|skfB]-[protein|search|skfC]-[protein|search|skfE]-[protein|search|skfF]-[protein|search|skfG]-[protein|search|skfH]' transcript. [http://www.ncbi.nlm.nih.gov/pubmed/16816204 PubMed]

    • References

    Reviews

  • 20955377

    • Original Publications

  • 12817086,15812018,16816204,14651647,15687200,15687200,17720793,17449691,18840696,27766092