yhdN [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

general stress protein, broad specificity aldo-keto reductase that converts MG to acetol

locus: BSU09530

pI: 4.00

mw: 37.00 kDa

function: detoxification of methylglyoxal

product: aldo/keto reductase, specific for NADP

essential: no

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.1|Biosynthesis of fatty acids]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of lipids], [SW|general stress proteins (controlled by SigB)], [SW|resistance against oxidative and electrophile stress]

This gene is a member of the following [SW|regulons]

• [SW|SigB regulon]

Gene

Coordinates on the chromosome (coding sequence): 1,030,265 -> 1,031,260

Phenotypes of a mutant

• increased sensitivity to methylglyoxal [Pubmed|24330391]

The protein

Catalyzed reaction/ biological activity

• methylglyoxal --> acetol [Pubmed|24330391]

Protein family

• aldo/keto reductase 2 family (according to Swiss-Prot)

Paralogous protein(s)

• [SW|IolS], [SW|YccK]

[SW|Cofactors]

• NADPH [Pubmed|24330391]

Structure

• [PDB|1PZ1] [Pubmed|15019785]

Expression and Regulation

Operon

• ''[protein|search|yhdN]-[protein|search|plsC]'' [Pubmed|10220166]

[SW|Sigma factor]

• [protein|search|SigB] [Pubmed|10220166,15805528]

Regulation

• induced by stress ([protein|search|SigB]) [Pubmed|10220166,15805528]

References

• 10220166,15019785,24330391,12737802,15805528