SubtiBank SubtiBank
yhdN
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

yhdN

general stress protein, broad specificity aldo-keto reductase that converts MG to acetol
Locus
BSU_09530
Isoelectric point
4.77
Molecular weight
37.16 kDa
Protein length
331 aa Sequence Blast
Gene length
996 bp Sequence Blast
Function
detoxification of methylglyoxal
Product
aldo/keto reductase, specific for NADP
Essential
no
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
Loading

Categories containing this gene/protein

  • Metabolism → Lipid metabolism → Biosynthesis of lipids → Biosynthesis of fatty acids
  • Lifestyles → Coping with stress → General stress proteins (controlled by SigB)
  • Lifestyles → Coping with stress → Resistance against oxidative and electrophile stress

    • Gene

    Coordinates
    1,030,265 1,031,260

    Phenotypes of a mutant

  • increased sensitivity to methylglyoxal PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • methylglyoxal ---> acetol PubMed

    • Protein family

  • Aldo/keto reductase family (according to UniProt)

    • Paralogous protein(s)

  • YccK, YcsN, IolS

    • Cofactors

  • NADPH PubMed

    • Structure

  • 1PZ1 PubMed

    • Expression and Regulation

    Operons

    Genes
    yhdN-plsC
    Description
    PubMed

    Sigma factors

  • SigB: sigma factor, PubMed, in SigB regulon

    • Regulatory mechanism

  • FapR: repression, PubMed, in FapR regulon

    • Regulation

  • induced by stress (SigB) PubMed
    • view in new tab

    Biological materials

    Mutant

  • MGNA-A695 (yhdN::erm), available at the NBRP B. subtilis, Japan
  • BKE09530 (yhdN::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTGTGCCACTCCTTCACT, downstream forward: _UP4_TAACAAAAGCTGAGGGCGAA
  • BKK09530 (yhdN::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTGTGCCACTCCTTCACT, downstream forward: _UP4_TAACAAAAGCTGAGGGCGAA

    • References

    Loading