helD [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

DNA 3-5 helicase IV, stimulates transcription in an ATP-dependent manner by enhancing transcriptional cycling and elongation

locus: BSU33450

pI: 6.00

mw: 89.00 kDa

function: transcription, DNA repair/ recombination

product: DNA 3-5 helicase IV

essential: no

ec: 3.6.4.12

synonyms: yvgS

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination]
• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins]

[SW|Categories] containing this gene/protein

• [SW|DNA repair/ recombination], [SW|transcription]

Gene

Coordinates on the chromosome (coding sequence): 3,434,327 -> 3,436,651

The protein

Protein family

• UvrD subfamily (according to Swiss-Prot)

Structure

• [PDB|3DMN] (C-terminal domain of the protein from ''Lactobacillus plantarum'', 39% identity)

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

[SW|Interactions]

• HelD interacts with the [SW|RNA polymerase] core enzyme [Pubmed|24520113,21710567]

Expression and Regulation

Operon

• ''[protein|search|helD]'' [Pubmed|22383849]

Biological materials

Mutant

• 1A899 ( ''helD''::''erm''), available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A899&Search=1A899 BGSC]
• BKE33450 (''[protein|search|helD]''::''erm'', available in the BGSC, in [SW|Fabian Commichau]'s, and in [SW|Jörg Stülke]'s lab)

References

• 24520113