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med [2018-09-25 09:53:26]
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med [2018-09-25 09:53:26]

lipoprotein, positive regulator of comK, stimulates KinD-dependent phosphorylation of Spo0A
locus
BSU11300
pI
4.60
mw
35.16 kDa
protein length
317 aa Sequence Blast
gene length
951 bp Sequence Blast
function
regulation of competence
product
positive regulator of comK
essential
no
synonyms
yjaW
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence]

    • Gene

    Coordinates
    1,206,629 → 1,207,582

    Phenotypes of a mutant

  • impaired biofilm formation [Pubmed|21622736]

    • The protein

    Catalyzed reaction/ biological activity

  • stimulates [protein|511E71BB1981758857854C8E9BF657287CE60C11|KinD]-dependent phosphorylation of [protein|2C54FE2ADC82FF414D732018C90649D477A925AD|Spo0A] [Pubmed|21622736]

    • Protein family

  • BMP lipoprotein family (according to Swiss-Prot)

    • [SW|Localization]

  • cell surface [Pubmed|12036071]

    • Expression and Regulation

    Operons

    genes
    [gene|D08B0A131374D2949ABC3EF8D6117C6BC6D94FE5|yjaV]-[gene|4DAB7847EA3848A34432C80124464543FA3DCA0F|med]-[gene|8914DE1312FD3C28E7D451A034814D92D1312B10|comZ]
    description
    [pubmed|22383849]

    sigma factors

  • [protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE]: sigma factor, [Pubmed|15699190], in [regulon|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE regulon]
    • view in new tab

    genes
    [gene|4DAB7847EA3848A34432C80124464543FA3DCA0F|med]-[gene|8914DE1312FD3C28E7D451A034814D92D1312B10|comZ]
    description
    [Pubmed|9335269]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|9335269], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|2C54FE2ADC82FF414D732018C90649D477A925AD|Spo0A]: repression, [Pubmed|14651647], in [regulon|2C54FE2ADC82FF414D732018C90649D477A925AD|Spo0A regulon]

    • regulation

  • repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]
    • view in new tab

    genes
    [gene|2BF1CA62F5B8B54A25B70721D39B5BD38C0203EB|yjaU]-[gene|D08B0A131374D2949ABC3EF8D6117C6BC6D94FE5|yjaV]-[gene|4DAB7847EA3848A34432C80124464543FA3DCA0F|med]-[gene|8914DE1312FD3C28E7D451A034814D92D1312B10|comZ]
    description
    [Pubmed|22383849]
    view in new tab

    Biological materials

    Mutant

  • BKE11300 (Δ[gene|4DAB7847EA3848A34432C80124464543FA3DCA0F|med]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE11300 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGTCATGTTCAACTCCTT, downstream forward: _UP4_AACGAGTAATGGAGTGACGT
  • BKK11300 (Δ[gene|4DAB7847EA3848A34432C80124464543FA3DCA0F|med]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK11300 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGTCATGTTCAACTCCTT, downstream forward: _UP4_AACGAGTAATGGAGTGACGT

    • References

  • 9335269,12036071,14651647