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med
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med

lipoprotein, positive regulator of [gene|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK], stimulates [protein|511E71BB1981758857854C8E9BF657287CE60C11|KinD]-dependent phosphorylation of [protein|2C54FE2ADC82FF414D732018C90649D477A925AD|Spo0A]
locus
BSU_11300
pI
4.60
mw
35.16 kDa
protein length
317 aa Sequence Blast
gene length
954 bp Sequence Blast
function
regulation of competence
product
positive regulator of [gene|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK]
essential
no
synonyms
yjaW
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence]

    • Gene

    Coordinates
    1,206,629 1,207,582

    Phenotypes of a mutant

  • impaired biofilm formation [Pubmed|21622736]

    • The protein

    Catalyzed reaction/ biological activity

  • stimulates [protein|511E71BB1981758857854C8E9BF657287CE60C11|KinD]-dependent phosphorylation of [protein|2C54FE2ADC82FF414D732018C90649D477A925AD|Spo0A] [Pubmed|21622736]

    • Protein family

  • BMP lipoprotein family (with [protein|19BA45BD691BBA4B23C4741C63DB729AA5D30FDA|NupN], according to UniProt)

    • Structure

  • [PDB|2HQB] (from B. halodurans, 49% identity) [pubmed|17636568]

    • [SW|Localization]

  • cell surface [Pubmed|12036071]

    • Expression and Regulation

    Operons

    genes
    [gene|D08B0A131374D2949ABC3EF8D6117C6BC6D94FE5|yjaV]-[gene|4DAB7847EA3848A34432C80124464543FA3DCA0F|med]-[gene|8914DE1312FD3C28E7D451A034814D92D1312B10|comZ]
    description
    [pubmed|22383849]

    sigma factors

  • [protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE]: sigma factor, [Pubmed|15699190], in [regulon|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE regulon]
    • view in new tab

    genes
    [gene|4DAB7847EA3848A34432C80124464543FA3DCA0F|med]-[gene|8914DE1312FD3C28E7D451A034814D92D1312B10|comZ]
    description
    [Pubmed|9335269]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|9335269], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|2C54FE2ADC82FF414D732018C90649D477A925AD|Spo0A]: repression, [Pubmed|14651647], in [regulon|2C54FE2ADC82FF414D732018C90649D477A925AD|Spo0A regulon]

    • regulation

  • repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]
    • view in new tab

    genes
    [gene|2BF1CA62F5B8B54A25B70721D39B5BD38C0203EB|yjaU]-[gene|D08B0A131374D2949ABC3EF8D6117C6BC6D94FE5|yjaV]-[gene|4DAB7847EA3848A34432C80124464543FA3DCA0F|med]-[gene|8914DE1312FD3C28E7D451A034814D92D1312B10|comZ]
    description
    [Pubmed|22383849]
    view in new tab

    Biological materials

    Mutant

  • BKE11300 ([gene|4DAB7847EA3848A34432C80124464543FA3DCA0F|med]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE11300 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGTCATGTTCAACTCCTT, downstream forward: _UP4_AACGAGTAATGGAGTGACGT
  • BKK11300 ([gene|4DAB7847EA3848A34432C80124464543FA3DCA0F|med]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK11300 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGTCATGTTCAACTCCTT, downstream forward: _UP4_AACGAGTAATGGAGTGACGT

    • References

  • 9335269,12036071,14651647,17636568