histidinol-phosphate aminotransferase / tyrosine and phenylalanine aminotransferase
function
biosynthesis of aromatic amino acids
product
histidinol-phosphate aminotransferase /
tyrosine and phenylalanine aminotransferase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.13|Biosynthesis/ acquisition of aromatic amino acids][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids]This gene is a member of the following [SW|regulons]
[SW|TRAP regulon]Gene
Coordinates on the chromosome (coding sequence)
2,370,415 -> 2,371,497
The protein
Catalyzed reaction/ biological activity
L-histidinol phosphate 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate L-glutamate (according to Swiss-Prot)Protein family
bacterial solute-binding protein 3 family (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|aroF]-[protein|search|aroB]-[protein|search|aroH]-[protein|search|trpE]-[protein|search|trpD]-[protein|search|trpC]-[protein|search|trpF]-[protein|search|trpB]-[protein|search|trpA]-[protein|search|hisC]-[protein|search|tyrA]-[protein|search|aroE]'' (according to [http://dbtbs.hgc.jp/COG/prom/trpEDCFBA-hisC-tyrA-aroE.html DBTBS])''[protein|search|trpE]-[protein|search|trpD]-[protein|search|trpC]-[protein|search|trpF]-[protein|search|trpB]-[protein|search|trpA]-[protein|search|hisC]-[protein|search|tyrA]-[protein|search|aroE]'' [Pubmed|21815947]''[protein|search|hisC]-[protein|search|tyrA]-[protein|search|aroE]'' [Pubmed|21815947][SW|Sigma factor]
''[protein|search|trpE]'': [protein|search|SigA] [Pubmed|6436812]Regulation
not expressed if tryptophan is available ([MtrB|search|TRAP]) [Pubmed|1551827]Regulatory mechanism
[MtrB|search|TRAP]: binding to the mRNA in the presence of tryptophan, this results in transcription termination [Pubmed|8419914]Additional information
the mRNA of the ''[protein|search|trpE]-[protein|search|trpD]-[protein|search|trpC]-[protein|search|trpF]-[protein|search|trpB]-[protein|search|trpA]-[protein|search|hisC]-[protein|search|tyrA]-[protein|search|aroE]'' operon strongly accumulates upon depletion of [rny|search|RNase Y] [Pubmed|21815947]the mRNA is substantially stabilized upon depletion of [Rny|search|RNase Y] [PubMed|21815947]References
4431,824269,11518529,3924737,6436812,1551827,8419914,21815947,23540922 
