comS [Wed Apr 06 2016 12:47:20 GMT+0200 (CEST)]

antiadaptor protein, assembly link between regulatory components of the competence signal transduction pathway

locus: BSU03500

pI: 9.00

mw: 5.00 kDa

function: control of ComK degradation

product: antiadaptor protein (anti-MecA)

essential: no

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence]
• [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence]
• [category|SW 6|Groups of genes] → [category|SW 6.8|Short peptides]

[SW|Categories] containing this gene/protein

• [SW|genetic competence], [SW|short peptides]

This gene is a member of the following [SW|regulons]

• [SW|Abh regulon], [SW|CodY regulon], [SW|ComA regulon], [SW|PerR regulon], [SW|Spx regulon]

Gene

Coordinates on the chromosome (coding sequence): 390,880 -> 391,020

Phenotypes of a mutant

• loss of [SW|genetic competence] [Pubmed|7752896]
• overexpression of [protein|search|ComS] results in expression of competence genes in 80% to 90% of the cells [Pubmed|8878039]

The protein

[SW|Interactions]

• [protein|search|MecA]-[protein|search|ComS] [Pubmed|10447896]

Expression and Regulation

Operon

• ''[SW|srfAA]-[SW|srfAB]-[protein|search|comS]-[SW|srfAC]-[SW|srfAD]'' [Pubmed|1715856]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|1715856]

Regulation

• repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|8830686]
• repressed during hydrogen peroxide stress ([protein|search|PerR]) [Pubmed|16166527]
• expressed at high cell density ([protein|search|ComA]) [Pubmed|16091051]

Regulatory mechanism

• [protein|search|CodY]: transcription repression [Pubmed|8830686]
• [protein|search|ComA]: transcription activation [Pubmed|1715856,16091051]
• [protein|search|PerR]: transcription activation [Pubmed|16166527]
• [protein|search|Spx]: transcription repression [Pubmed|12642660]
• [protein|search|Abh]: transcription repression[Pubmed|20817675]

References

Reviews

• 19609260

Original Publications

• 17560370,10447896,12642660,9000055,10361283,10447896,11703662,1715856,16091051,20817675,8878039,7752896