comS

antiadaptor protein, assembly link between regulatory components of the competence signal transduction pathway

Locus: BSU_03500

Isoelectric point: 9.15

Molecular weight: 5.11 kDa

Protein length: 46 aa

Gene length: 141 bp

Function: control of ComK degradation

Product: antiadaptor protein (anti-MecA)

Essential: no

Synonyms

Genomic Context

Loading

Categories containing this gene/protein

• Information processing → Genetics → Genetic competence
• Lifestyles → Exponential and early post-exponential lifestyles → Genetic competence
• Groups of genes → Short peptides

Gene

Coordinates: 390,880 391,020

Phenotypes of a mutant

• loss of genetic competence PubMed
• overexpression of ComS results in expression of competence genes in 80% to 90% of the cells PubMed

Expression and Regulation

Operons

• Genes: srfAA-srfAB-comS-srfAC-srfAD
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • PhoP: activation, PubMed, in PhoP regulon
  • CodY: repression, PubMed, in CodY regulon
  • ComA: activation, PubMed, in ComA regulon
  • PerR: activation, PubMed, in PerR regulon
  • Spx: repression, PubMed, in Spx regulon
  • Abh: repression, PubMed, in Abh regulon

  Regulation

  • expressed at high cell density (ComA) PubMed

  Additional information

  • A ncRNA is predicted between 'hxlR' and 'srfAA' PubMed

Biological materials

Mutant

• BKE03500 (comS::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CTTGCCTGATCGGTTCAAACG, downstream forward: _UP4_AAGTAGATAAAGACCGGCTTG
• BKK03500 (comS::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CTTGCCTGATCGGTTCAAACG, downstream forward: _UP4_AAGTAGATAAAGACCGGCTTG

References

Reviews

Loading

Original Publications

Loading