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mtlD [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]
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mtlD [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]

mannitol-1-phosphate 5-dehydrogenase
locus
BSU03990
pI
6.29
mw
40.00 kDa
function
mannitol utilization
product
mannitol-1-phosphate 5-dehydrogenase
essential
no
ec
1.1.1.17
synonyms
mtlB
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.10|Utilization of mannitol]

    • [SW|Categories] containing this gene/protein

  • [SW|utilization of specific carbon sources]

    • This gene is a member of the following [SW|regulons]

  • [SW|MtlR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    451,618 -> 452,739

    The protein

    Catalyzed reaction/ biological activity

  • D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH (according to Swiss-Prot)

    • Protein family

  • mannitol dehydrogenase family (according to Swiss-Prot)

    • Structure

  • [PDB|3H2Z] (from ''Shigella flexneri 2a str. 2457t mutant'', 42% identity, 59% similarity)

    • Expression and Regulation

    Operon

  • ''[protein|search|mtlA]-[protein|search|mtlF]-[protein|search|mtlD]'' [Pubmed|12897001]

    • Regulation

  • induced by mannitol ([protein|search|MtlR]) [Pubmed|20444094]
  • repressed by glucose ([protein|search|MtlR]) [Pubmed|20444094]

    • Regulatory mechanism

  • [protein|search|MtlR]: transcription activation [Pubmed|20444094]

    • Additional information

  • An [ncRNA|search|antisense RNA] is predicted for '[protein|search|mtlD]' [PubMed|20525796]

    • References

  • 12897001,20444094,10627040,20525796