phospho-N-acetylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate), catalyzes the first commited membrane-bound step of bacterial peptidoglycan synthesis leading to the formation of lipid I
function
peptidoglycan precursor biosynthesis
product
phospho-N-acetylmuramoyl-pentapeptide-transferase
(meso-2,6-diaminopimelate)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|cell wall synthesis], [SW|biosynthesis of cell wall components], [SW|essential genes], [SW|membrane proteins]Gene
Coordinates on the chromosome (coding sequence)
1,587,926 -> 1,588,900
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) undecaprenyl phosphate = UMP Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol (according to Swiss-Prot)Protein family
MraY subfamily (according to Swiss-Prot)[SW|Localization]
cell membrane (according to Swiss-Prot)forms banded patterns along the length of the cell, this pattern formation depends on [SW|MreB] [Pubmed|20233306]Expression and Regulation
Operon
''[protein|search|murE]-[protein|search|mraY]-[protein|search|murD]-[SW|spoVE]-[protein|search|murG]-[protein|search|murB]-[SW|divIB]-[protein|search|ylxW]-[protein|search|ylxX]-[protein|search|sbp]'' [Pubmed|1391053]Regulation
expressed during vegatative growth [Pubmed|1391053]Biological materials
FLAG-tag construct
GP2001 ''mraY-3xFLAG ermC'' (based on [SW|pGP1087]), available in [SW|Jörg Stülke]'s labReferences
15131133,8436954,18791230,18081839,7734839,21937437,18672909,20537545,10790316,1391053,24895118,25127465,26620564,20233306,27226570,27312048,27531195 
