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mraY [2019-07-01 09:46:21]

phospho-N-acetylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate), catalyzes the first commited membrane-bound step of bacterial peptidoglycan synthesis leading to the formation of lipid I

Locus

BSU15190

Isoelectric point

8.97

Molecular weight

35.44 kDa

Protein length

324 aa Sequence Blast

Gene length

975 bp Sequence Blast

Function

peptidoglycan precursor biosynthesis

Product

phospho-N-acetylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate)

Essential

yes

E.C.

2.7.8.13

Synonyms

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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Categories containing this gene/protein

Cellular processes → Cell envelope and cell division → Cell wall synthesis → Biosynthesis of peptidoglycan

Metabolism → Additional metabolic pathways → Biosynthesis of cell wall components → Biosynthesis of peptidoglycan

Groups of genes → Essential genes

Groups of genes → Membrane proteins

Gene

Coordinates

1,587,926 1,588,900

Phenotypes of a mutant

essential PubMed

The protein

Catalyzed reaction/ biological activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) undecaprenyl phosphate = UMP Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol (according to Swiss-Prot)

Protein family

MraY subfamily (according to Swiss-Prot)

Structure

5JNQ PubMed

Localization

cell membrane (according to UniProt)

forms banded patterns along the length of the cell, this pattern formation depends on MreB PubMed

Expression and Regulation

Operons

Genes