pucG [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

(S)-ureidoglycine-glyoxylate aminotransferase

locus: BSU32520

pI: 5.42

mw: 45.00 kDa

function: purine utilization

product: (S)-ureidoglycine-glyoxylate aminotransferase

essential: no

synonyms: yurG

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.1|Utilization of nucleotides]

[SW|Categories] containing this gene/protein

• [SW|utilization of nucleotides]

This gene is a member of the following [SW|regulons]

• [SW|PucR regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,341,166 -> 3,342,416

The protein

Catalyzed reaction/ biological activity

• transamination between an unstable intermediate ((S)-ureidoglycine) and the end product of purine catabolism (glyoxylate) to yield oxalurate and glycine [Pubmed|20852637]

Protein family

• class-V pyridoxal-phosphate-dependent aminotransferase family (according to Swiss-Prot)

Structure

• [PDB|3ISL] [Pubmed|20852637]

Expression and Regulation

Operon

• ''[protein|search|pucF]-[protein|search|pucG]'' [Pubmed|12029039]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|12029039]

Regulation

• induced in the presence of purine nucleotides (inducer: allantoin) ([protein|search|PucR]) [Pubmed|12029039]

Regulatory mechanism

• [protein|search|PucR]: transcription activation [Pubmed|12029039]

References

• 11344136,20852637,12029039