cytochrome P450 (CYP102A3)/ NADPH-cytochrome P450 reductase
function
fatty acid metabolism
product
NADPH-cytochrome P450 reductase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.3|Electron transport/ other][category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.3|Lipid metabolism/ other][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)][SW|Categories] containing this gene/protein
[SW|electron transport/ other], [SW|lipid metabolism/ other], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|FatR regulon], [SW|SigM regulon], [SW|SigW regulon], [SW|SigX regulon]Gene
Coordinates on the chromosome (coding sequence)
2,773,890 -> 2,777,054
The protein
Catalyzed reaction/ biological activity
hydroxylates medium-chain fatty acids in subterminal positions [Pubmed|14741768]Paralogous protein(s)
[protein|search|YetO]Structure
[PDB|2X7Y] (from Bacillus megaterium; 67% identity, 88% similarity) [Pubmed|25325618,22949185][SW|Localization]
cell membrane (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|fatR]-[protein|search|yrhJ]'' [Pubmed|10917605]''[protein|search|yrhH]-[protein|search|fatR]-[protein|search|yrhJ]'' [Pubmed|18179421][SW|Sigma factor]
[protein|search|SigM] [Pubmed|12775685], [protein|search|SigW] [Pubmed|12207695], [protein|search|SigX] [Pubmed|9636707]Regulation
induced by unsaturated fatty acids ([protein|search|FatR]) [Pubmed|11734890]expression is reduced in a [protein|search|SigV] mutant [Pubmed|21926231]Regulatory mechanism
[protein|search|FatR]: transcription repression [Pubmed|11734890]Additional information
A [protein|search|ncRNA] ([SW|RnaC]) is encoded between '[protein|search|yrhK]' and '[protein|search|yrhJ]' [PubMed|25790031]References
11734890,10917605,11574077,14741768,15122913,12775685,16716428,16381045,20525796,12207695,9636707,21926231,25325618,22949185,25790031 
