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tetB [2018-10-04 20:19:10]
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tetB [2018-10-04 20:19:10]

multifunctional tetracycline/Na+ resistance protein
locus
BSU40770
pI
9.54
mw
49.59 kDa
protein length
458 aa Sequence Blast
gene length
1374 bp Sequence Blast
function
resistance to tetracyclin
product
multifunctional tetracycline/Na+ resistance protein
essential
no
synonyms
tetA, tetA(L)
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.12|Other transporters]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    4,187,681 → 4,189,057

    The protein

    Protein family

  • TCR/tet family (according to Swiss-Prot)

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|55C9FA5282B213915C164B46119C482D03491381|tetL]-[gene|4B900A64A96696F48BB0C2DC3B0884CD2F5E298B|tetB]
    description
    (according to [http://dbtbs.hgc.jp/COG/prom/tetLB.html DBTBS]) null

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|2844262], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
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    Biological materials

    Mutant

  • GP2080 (''[gene|4B900A64A96696F48BB0C2DC3B0884CD2F5E298B|tetB]''::''cat''), available in [SW|Jörg Stülke]'s lab
  • GP2081 (''[gene|4B900A64A96696F48BB0C2DC3B0884CD2F5E298B|tetB]''::''ermC''), available in [SW|Jörg Stülke]'s lab
  • BKE40770 (Δ[gene|4B900A64A96696F48BB0C2DC3B0884CD2F5E298B|tetB]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE40770 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACAATTTCCCCTCCATTAA, downstream forward: _UP4_TAAATGAGTGAAAGGATCAA
  • BKK40770 (Δ[gene|4B900A64A96696F48BB0C2DC3B0884CD2F5E298B|tetB]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK40770 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACAATTTCCCCTCCATTAA, downstream forward: _UP4_TAAATGAGTGAAAGGATCAA

    • Labs working on this gene/protein

  • [SW|David Bechhofer], Mount Sinai School, New York, USA [http://www.mountsinai.org/Research/Centers%20Laboratories%20and%20Programs/Bechhofer%20Laboratory?citype=Physician&ciid=Bechhofer%20David%20H%201255565 Homepage]

    • References

  • 8631673,10735849,8962071,9988470,8849239,2844262,25169108