function
biosynthesis of threonine
product
threonine synthase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.6|Biosynthesis/ acquisition of lysine/ threonine][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids], [SW|most abundant proteins]This gene is a member of the following [SW|regulons]
[SW|CodY regulon], [SW|ThrR regulon]Gene
Coordinates on the chromosome (coding sequence)
3,313,770 -> 3,314,828
The protein
Catalyzed reaction/ biological activity
O-phospho-L-homoserine H2O = L-threonine phosphate (according to Swiss-Prot) Protein family
serine/threonine dehydratase family (according to Swiss-Prot)Structure
[PDB|1UIN] (from ''Thermus thermophilus'', 51% identity, 69% similarity) [Pubmed|12952961]Expression and Regulation
Operon
''[protein|search|hom]-[protein|search|thrC]-[protein|search|thrB]'' [Pubmed|12107147]Regulation
repressed by casamino acids [Pubmed|12107147]repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|24163341]expressed in the presence of lysine or cysteine ([SW|ThrR]) [Pubmed|27260660]Regulatory mechanism
[protein|search|CodY]: transcription repression [Pubmed|24163341][protein|search|ThrR]: transcription repression [Pubmed|27260660]Additional information
belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]Biological materials
Mutant
1A773 ( ''thrC''::''cat''), [Pubmed|8973347], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A773&Search=1A773 BGSC] and in [SW|Jörg Stülke]'s labGP1783 ( ''ilvA2 thrR thrC''::''cat'') available in [SW|Jörg Stülke]'s labReferences
12107147,3098560,24163341,15378759,27260660 
