thrC [Wed Dec 14 2016 16:43:15 GMT+0100 (CET)]

threonine synthase

Locus: BSU32250

Isoelectric point: 5.00

Molecular weight: 37.00 kDa

Function: biosynthesis of threonine

Product: threonine synthase

Essential: no

E.C.: 4.2.3.1

Synonyms: thrB

Genomic Context

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Categories containing this gene/protein

• Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of lysine/ threonine

Categories containing this gene/protein

• biosynthesis/ acquisition of amino acids, most abundant proteins

This gene is a member of the following regulons

• CodY regulon, ThrR regulon

Gene

Coordinates on the chromosome (coding sequence): 3,313,770 -> 3,314,828

The protein

Catalyzed reaction/ biological activity

• O-phospho-L-homoserine H₂O = L-threonine phosphate (according to Swiss-Prot)

Protein family

• serine/threonine dehydratase family (according to Swiss-Prot)

Structure

• 1UIN (from Thermus thermophilus, 51% identity, 69% similarity) PubMed

Expression and Regulation

Operon

• hom-thrC-thrB PubMed

Regulation

• repressed by casamino acids PubMed
• repressed during growth in the presence of branched chain amino acids (CodY) PubMed
• expressed in the presence of lysine or cysteine (ThrR) PubMed

Regulatory mechanism

• CodY: transcription repression PubMed
• ThrR: transcription repression PubMed

Additional information

• belongs to the 100 most abundant proteins PubMed

Biological materials

Mutant

• 1A773 ( thrC::cat), PubMed, available at BGSC and in Jörg Stülke's lab
• 1A773 ( ilvA2 thrR thrC::cat) available in Jörg Stülke's lab

References

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