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iolT [2019-05-02 17:56:21]
major transporter for inositol
function
myo-inositol uptake
product
major transporter for inositol
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.3|Carbohydrate transporter][category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.16|Utilization of inositol][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]Gene
Coordinates
676,442 677,863
The protein
Catalyzed reaction/ biological activity
transport of myo-inositol [Pubmed|20530884]Protein family
[SW|major facilitator superfamily] (according to UniProt)Paralogous protein(s)
[protein|4A77316AA94F9C11DB70AB76711AACBD28098AA1|IolT], [protein|770D9A5BEEEABE9C3FC772E74001329206ECFAB3|AraE], [protein|7CE5A42042E5D52768735E795DB805530691D8A6|YwtG], [protein|8B0701B5694ABA8142476CB896E590FE1981D7DB|YfiG], [protein|A84AC4E40E7C722E27AE9C24ACECFEABD51B57BE|YncC], [protein|0757FAEB38AA1C599C5067794AF83A4BA5912DC9|CsbC], [protein|4A77316AA94F9C11DB70AB76711AACBD28098AA1|IolT] Structure
[PDB|4LDS] (glucose transporter from Staphylococcus epidermidis, 36% identity) [pubmed|24127585][SW|Localization]
cell membrane (according to Swiss-Prot)Expression and Regulation
Operons
genes
[gene|4A77316AA94F9C11DB70AB76711AACBD28098AA1|iolT]
description
[pubmed|22383849]
regulatory mechanism
[protein|5F4ABBC8ECAD6F6C10EC39B2B0F0BC73F11522CE|IolR]: repression, [pubmed|11807058], in [regulon|5F4ABBC8ECAD6F6C10EC39B2B0F0BC73F11522CE|IolR regulon]regulation
induced in the presence of inositol ([protein|5F4ABBC8ECAD6F6C10EC39B2B0F0BC73F11522CE|IolR]) [Pubmed|11807058]view in new tabBiological materials
Mutant
MGNA-C218 (ydjK::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2216 NBRP B. subtilis, Japan]BKE06230 ([gene|4A77316AA94F9C11DB70AB76711AACBD28098AA1|iolT]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE06230 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACTGTTTCCCCCAGTCT, downstream forward: _UP4_TAATTTAAAAAAGAATCCGCBKK06230 ([gene|4A77316AA94F9C11DB70AB76711AACBD28098AA1|iolT]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK06230 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACTGTTTCCCCCAGTCT, downstream forward: _UP4_TAATTTAAAAAAGAATCCGCReferences
11807058,20530884,28431560,24127585