uppS [Tue Dec 13 2016 11:16:33 GMT+0100 (CET)]

undecaprenyl pyrophosphate synthetase, provides the precursor for the carrier lipid, undecaprenyl phosphate (C55-P), which is required for cell wall synthesis

locus: BSU16530

pI: 5.00

mw: 29.00 kDa

function: cell wall biosynthesis

product: undecaprenyl pyrophosphate synthetase

essential: yes

ec: 2.5.1.31

synonyms: yluA

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.8|Biosynthesis of the carrier lipid undecaprenylphosphate]
• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.3|Biosynthesis of isoprenoids]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.5|Biosynthesis of the carrier lipid undecaprenylphosphate]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|cell wall synthesis], [SW|biosynthesis of lipids], [SW|essential genes]

Gene

Coordinates on the chromosome (coding sequence): 1,721,214 -> 1,721,996

Phenotypes of a mutant

• essential [Pubmed|22904278]
• ''uppS'' is dispensable in wall-less L-forms [Pubmed|24704074]
• the ''[SW|uppS86]'' (C257T) mutation provides resistance to rare earth metals such as scandium and to bacitracin [Pubmed|22904278]

The protein

Catalyzed reaction/ biological activity

• catalyzes eight consecutive condensation reactions of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosphate (FPP) to form undecaprenyl pyrophosphate

Protein family

• UPP synthetase family (according to Swiss-Prot)

Structure

• [PDB|1X09] (the protein from ''E. coli'', 49% identity, 77% similarity) [Pubmed|15788389]

References

• 22904278,23796923,15788389,23840410,24704074,27578312