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liaR [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]
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liaR [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

two-component response regulator, regulation of the liaI-liaH-liaG-liaF-liaS-liaR operon in response to bacitracin
locus
BSU33080
pI
4.00
mw
22.00 kDa
function
regulation of the liaI-liaH-liaG-liaF-liaS-liaR operon
product
two-component response regulator
essential
no
synonyms
yvqC
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.1|Two-component system response regulators]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.2|Phosphorylation on an Asp residue]

    • [SW|Categories] containing this gene/protein

  • [SW|transcription factors and their control], [SW|resistance against oxidative and electrophile stress], [SW|resistance against toxins/ antibiotics], [SW|phosphoproteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|LiaR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,394,422 -> 3,395,057

    The protein

    Catalyzed reaction/ biological activity

  • regulation of the ''[protein|search|liaI]-[protein|search|liaH]-[protein|search|liaG]-[protein|search|liaF]-[protein|search|liaS]-[protein|search|liaR]'' operon in response to bacitracin

    • Modification

  • phosphorylation on a Asp residue by [protein|search|LiaS]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • [SW|Interactions]

  • [protein|search|LiaS]-[protein|search|LiaR]

    • Expression and Regulation

    Operon

  • ''[protein|search|liaI]-[protein|search|liaH]-[protein|search|liaG]-[protein|search|liaF]-[protein|search|liaS]-[protein|search|liaR]'' [Pubmed|14651641]
  • ''[protein|search|liaG]-[protein|search|liaF]-[protein|search|liaS]-[protein|search|liaR]'' [Pubmed|16816187]

    • [SW|Sigma factor]

  • ''liaI'': [protein|search|SigA] [Pubmed|15273097]
  • ''liaG'': [protein|search|SigA] [Pubmed|16816187]

    • Regulation

  • ''[protein|search|liaI]'': induced by bacitracin and rhamnolipids ([protein|search|LiaR]) [Pubmed|16816187,22092710]
  • induced by daptomycin [Pubmed|27791134]
  • ''[protein|search|liaI]'': repressed during logarithmic growth ([protein|search|AbrB]) [PubMed|15101989,17660417], indirect regulation by [protein|search|AbrB] [Pubmed|20817675]
  • ''[protein|search|liaG]'': constitutive

    • Regulatory mechanism

  • [protein|search|LiaR]: transcription activation [Pubmed|16816187]

    • Labs working on this gene/protein

  • [SW|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]

    • References

    Reviews

  • 27344142

    • Original publications

  • 18394148,19164152,15273097,17921301,10094672,19164157,14651641,17600057,17660417,16816187,15101989,17660417,20057163,20817675,20639339,23279150,22964256,22092710,23326432,27791134,27856233