maf [Tue Dec 08 2015 12:51:49 GMT+0100 (CET)]

nucleotide pyrophosphatase, cell division inhibitor in competent cells, blocks septation during the escape from competence, required for the stability of ComGA

locus: BSU28050

pI: 5.00

mw: 21.00 kDa

function: cell division control

product: nucleotide pyrophosphatase

essential: no

synonyms

Genomic Context

categories

• [category|SW 6|Groups of genes] → [category|SW 6.7|Proteins of unknown function]

[SW|Categories] containing this gene/protein

• [SW|cell division], [SW|genetic competence]

This gene is a member of the following [SW|regulons]

• [SW|ComK regulon]

Gene

Coordinates on the chromosome (coding sequence): 2,862,572 -> 2,863,141

The protein

Catalyzed reaction/ biological activity

• nucleotide pyrophosphatase [Pubmed|24210219]

Protein family

• maf family (according to Swiss-Prot)

[SW|Cofactors]

• binds phosphorylated compounds (UTP, IMP, IDP, GDP and others) in ''in vitro'' experiments

Structure

• [PDB|1EX2] [Pubmed|10841541]

[SW|Localization]

• cytosolic protein [Pubmed|24164455]
• near the poles of competent cells [Pubmed|21564336]

[SW|Interactions]

• forms dimers [Pubmed|10841541,21564336]
• [protein|search|Maf]-[SW|DivIVA] [Pubmed|21564336]
• [protein|search|Maf]-[protein|search|FtsW] [Pubmed|21564336]
• [protein|search|Maf]-[SW|ComGA] [Pubmed|21564336]

Expression and Regulation

Regulation

• expressed when cells enter the compentent state ([protein|search|ComK]) [Pubmed|11948146]
• expression is reduced in a [protein|search|SigV] mutant [Pubmed|21926231]

Regulatory mechanism

• [protein|search|ComK]: transcription activation [Pubmed|21564336]

References

Reviews

• 21595759

Original publications

• 21564336,10841541,8387996,11948146,24164455,21926231,24210219