anthranilate synthase (subunit I)
function
biosynthesis of tryptophan
product
anthranilate synthase (subunit I)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.13|Biosynthesis/ acquisition of aromatic amino acids][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids]This gene is a member of the following [SW|regulons]
[SW|TRAP regulon]The protein
Catalyzed reaction/ biological activity
Chorismate L-glutamine = anthranilate pyruvate L-glutamate (according to Swiss-Prot)Effectors of protein activity
subject to feedback inhibtion by tryptophan [Pubmed|4956345]Structure
[PDB|1I7Q] (from ''Serratia marcescens'', 42% identity, 62% similarity) [Pubmed|11371633][SW|Interactions]
[protein|search|PabA]-[protein|search|TrpE]Expression and Regulation
Operon
''[protein|search|aroF]-[protein|search|aroB]-[protein|search|aroH]-[protein|search|trpE]-[protein|search|trpD]-[protein|search|trpC]-[protein|search|trpF]-[protein|search|trpB]-[protein|search|trpA]-[protein|search|hisC]-[protein|search|tyrA]-[protein|search|aroE]'' (according to [http://dbtbs.hgc.jp/COG/prom/trpEDCFBA-hisC-tyrA-aroE.html DBTBS])''[protein|search|trpE]-[protein|search|trpD]-[protein|search|trpC]-[protein|search|trpF]-[protein|search|trpB]-[protein|search|trpA]-[protein|search|hisC]-[protein|search|tyrA]-[protein|search|aroE]'' [Pubmed|21815947]''[protein|search|trpE]-[protein|search|trpD]-[protein|search|trpC]-[protein|search|trpF]-[protein|search|trpB]-[protein|search|trpA]'' [Pubmed|21815947][SW|Sigma factor]
''[protein|search|trpE]'': [protein|search|SigA] [Pubmed|6436812]Regulation
not expressed if tryptophan is available ([MtrB|search| TRAP]) [Pubmed|1551827]Regulatory mechanism
[MtrB|search| TRAP]: binding to the mRNA in the presence of tryptophan, this results in transcription termination [Pubmed|8419914]Additional information
the mRNA of the operon strongly accumulates upon depletion of [rny|search|RNase Y] [Pubmed|21815947]References
Reviews
The ''trpE'' [SW|RNA switch]
20384694,19033375,17881743,7515880,2422155,3133360,7678334,7592410,14976255,2422155,8419914,1551827,16285852,10714985,11566991,12963367,14712717,21097886,24505391,24682818 Other original publications
4956345,3924737,6436812,21815947 
