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qoxA [Mon Feb 01 2016 10:35:01 GMT+0100 (CET)]
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qoxA [Mon Feb 01 2016 10:35:01 GMT+0100 (CET)]

cytochrome aa3 quinol oxidase (subunit II)
locus
BSU38170
pI
4.00
mw
36.00 kDa
function
respiration
product
cytochrome aa3 quinol oxidase (subunit II)
essential
no
ec
1.10.3.-
synonyms
ipa-37d
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.2|Respiration] → [category|SW 2.1.2.1|Terminal oxidases]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|respiration], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|stringent response]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,917,296 -> 3,918,261

    Phenotypes of a mutant

  • inactivation of ''[protein|search|qoxA]'' restores beta-lactam resistance in a ''[protein|search|sigM]'' mutant [Pubmed|22211522]

    • The protein

    Catalyzed reaction/ biological activity

  • Ubiquinol-8 O2 = Ubiquinone-8 H2O (according to Swiss-Prot)

    • Protein family

  • cytochrome c oxidase subunit 2 family (according to Swiss-Prot)

    • Structure

  • [PDB|1FFT] ([SW|QoxA]-[SW|QoxB]-[SW|QoxC] complex from ''E. coli'', 35% identity)

    • [SW|Localization]

  • cell membrane[Pubmed|18763711]

    • Expression and Regulation

    Operon

  • ''[protein|search|qoxA]-[protein|search|qoxB]-[protein|search|qoxC]-[protein|search|qoxD]'' [Pubmed|1316894]

    • Regulation

  • [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]

    • References

  • 11073895,1316894,20351111,10551842,18763711,24779955,22211522