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qoxA [2019-06-06 11:31:30]
cytochrome aa3 quinol oxidase (subunit II)
product
cytochrome aa3 quinol oxidase (subunit II)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.2|Respiration] → [category|SW 2.1.2.1|Terminal oxidases][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]Gene
Coordinates
3,917,296 3,918,261
Phenotypes of a mutant
inactivation of ''[gene|48A9E1E39838BFFCF12CADF0A8D8E6FFDCA6F175|qoxA]'' restores beta-lactam resistance in a ''[gene|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]'' mutant [Pubmed|22211522]The protein
Catalyzed reaction/ biological activity
Ubiquinol-8 + O2 = Ubiquinone-8 + H2O (according to Swiss-Prot)Protein family
cytochrome c oxidase subunit 2 family (according to Swiss-Prot)Structure
[PDB|1FFT] ([protein|48A9E1E39838BFFCF12CADF0A8D8E6FFDCA6F175|QoxA]-[protein|CBF2DCFFD8195304F942ECBA8596444F0AC47CC6|QoxB]-[protein|CD4520EF427AEFDCF028AE063BC373FA6DCE379E|QoxC] complex from ''E. coli'', 35% identity) [Pubmed|11017202][SW|Localization]
cell membrane[Pubmed|18763711]Expression and Regulation
Operons
genes
[gene|48A9E1E39838BFFCF12CADF0A8D8E6FFDCA6F175|qoxA]-[gene|CBF2DCFFD8195304F942ECBA8596444F0AC47CC6|qoxB]-[gene|CD4520EF427AEFDCF028AE063BC373FA6DCE379E|qoxC]-[gene|03335DC50CED7B38E2380640AE108ADA09A2CBDF|qoxD]
description
[Pubmed|1316894]
regulatory mechanism
[regulon|stringent response|stringent response]: negative regulation, in [regulon|stringent response|stringent response][protein|E15E9F88B0E03FE8834C646369D2F4B4E713EF41|CitB]: mRNA binding, in [regulon|E15E9F88B0E03FE8834C646369D2F4B4E713EF41|CitB regulon]regulation
[protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]additional information
the presence of an iron-responsive element bound by [SW|CitB] between ''[SW|feuA]'' and ''[SW|feuB]'' suggests iron-dependent regulation by [SW|CitB] [Pubmed|10468622]view in new tabBiological materials
Mutant
BKE38170 ([gene|48A9E1E39838BFFCF12CADF0A8D8E6FFDCA6F175|qoxA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE38170 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACCATCCTTCCTATTGATG, downstream forward: _UP4_TGATATTGATCAGGAAAGGABKK38170 ([gene|48A9E1E39838BFFCF12CADF0A8D8E6FFDCA6F175|qoxA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK38170 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACCATCCTTCCTATTGATG, downstream forward: _UP4_TGATATTGATCAGGAAAGGAReferences
11073895,1316894,20351111,10551842,18763711,24779955,22211522,11017202,27503613