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tenA [Thu Jan 14 2016 18:44:19 GMT+0100 (CET)]
function
thiamine salvage
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.3|Biosynthesis/ acquisition of thiamine][SW|Categories] containing this gene/protein
[SW|biosynthesis of cofactors], [SW|most abundant proteins]This gene is a member of the following [SW|regulons]
[SW|Thi-box]Gene
Coordinates on the chromosome (coding sequence)
1,242,449 -> 1,243,159
The protein
Catalyzed reaction/ biological activity
Thiamine H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine 5-(2-hydroxyethyl)-4-methylthiazole (according to Swiss-Prot)Protein family
thiaminase-2 family (according to Swiss-Prot)Structure
[PDB|1YAF], [PDB|2QCX] (complex with formyl aminommethyl pyrimidine)Expression and Regulation
Operon
''[protein|search|tenA]-[protein|search|tenI]-[protein|search|thiO]-[protein|search|thiS]-[protein|search|thiG]-[protein|search|thiF]-[protein|search|thiD]'' [Pubmed|1898926]Regulation
repressed by thiamine ([protein|search|Thi-box]) [Pubmed|16356850]Regulatory mechanism
[protein|search|Thi-box]: [SW|RNA switch] [Pubmed|16356850]Additional information
belongs to the 100 [[most abundant proteins]] [PubMed|15378759]References
Reviews
Original publications
15709744,18054064,17618314,16356850,24311574,15378759 
