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fadN [2017-8-11 16:0:3]
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fadN [2017-8-11 16:0:3]

3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)
Locus
BSU32840
Isoelectric point
6.53
Molecular weight
89.96 kDa
Protein length
815 aa Sequence Blast
Gene length
2445 bp Sequence Blast
Function
fatty acid degradation
Product
3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)
Essential
no
E.C.
1.1.1.35
Synonyms
yusL
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Lipid metabolism → Utilization of lipids → Utilization of fatty acids

    • Gene

    Coordinates
    3,370,025 → 3,372,472

    The protein

    Catalyzed reaction/ biological activity

  • (S)-3-hydroxyacyl-CoA NAD = 3-oxoacyl-CoA NADH (according to Swiss-Prot)

    • Protein family

  • 3-hydroxyacyl-CoA dehydrogenase family (according to Swiss-Prot)

    • Cofactors

  • FMN or FAD PubMed

    • Expression and Regulation

    Operons

    Genes
    fadN-fadA-fadE
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • SdpR: activation, PubMed, in SdpR regulon
  • FadR: repression, PubMed, in FadR regulon
  • CcpA: repression, PubMed, in CcpA regulon

    • Regulation

  • FadN: induced by long-chain fatty acids (FadR) PubMed
  • expression of the operon is induced during biofilm formation PubMed
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    Genes
    fadM-fadN-fadA-fadE
    Description
    PubMed

    Regulatory mechanism

  • FadR: repression, PubMed, in FadR regulon
  • SdpR: activation, PubMed, in SdpR regulon

    • Regulation

  • fadM: induced by long-chain fatty acids (FadR) PubMed
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    Biological materials

    Mutant

  • MGNA-A604 (yusL::erm), available at the NBRP B. subtilis, Japan

    • References

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