qdoR

transcriptional regulator (TetR family), control of qdoI-yxaH and lmrA-lmrB

Locus: BSU_39990

Isoelectric point: 6.11

Molecular weight: 20.87 kDa

Protein length: 191 aa

Gene length: 576 bp

Function: control of quercetin utilization

Product: transcriptional regulator

Essential: no

Synonyms: yxaF

Genomic Context

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Categories containing this gene/protein

• Information processing → Regulation of gene expression → Transcription factors and their control → Transcription factors/ other
• Lifestyles → Coping with stress → Resistance against other toxic compounds (nitric oxide, phenolic acids, flavonoids, oxalate)

Gene

Coordinates: 4,107,352 4,107,927

The protein

Protein family

• TetR family

Paralogous protein(s)

• LmrA

Domains

• HTH tetR-type domain (aa 5-65) (according to UniProt)

Effectors of protein activity

• flavonoids such as quercetin act as molecular inducers and result in release from DNA targets PubMed

Structure

• 1SGM PubMed

Expression and Regulation

Operons

• Genes: qdoR
  Description: PubMed

  Regulatory mechanism

  • LmrA: repression, PubMed, in LmrA regulon
  • QdoR: repression, PubMed, in QdoR regulon

  Regulation

  • induced by flavonoids such as quercetin (QdoR, LmrA) PubMed

Biological materials

Mutant

• MGNA-B683 (yxaF::erm), available at the NBRP B. subtilis, Japan
• BKE39990 (qdoR::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTAAAACATTCCCTCCTA, downstream forward: _UP4_TAGCATTTTGTTATCCTTTC
• BKK39990 (qdoR::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTAAAACATTCCCTCCTA, downstream forward: _UP4_TAGCATTTTGTTATCCTTTC

Labs working on this gene/protein

• Yasutaro Fujita, University of Fukuyama, Japan

References

Reviews

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Original publications

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