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mgtE [2019-08-28 09:19:20]

primary magnesium transporter

Locus

BSU_13300

Isoelectric point

4.61

Molecular weight

50.68 kDa

Protein length

451 aa Sequence Blast

Gene length

1356 bp Sequence Blast

Function

magnesium uptake

Product

primary magnesium transporter

Essential

yes

Synonyms

ykoK

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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Categories containing this gene/protein

Cellular processes → Transporters → Transporters/ other → Metal ion transporter

Cellular processes → Homeostasis → Metal ion homeostasis (K, Na, Ca, Mg) → Magnesium uptake/ efflux

Information processing → Targets of second messengers → Targets of c-di-AMP

Groups of genes → Essential genes

Groups of genes → Membrane proteins

Gene

Coordinates

1,396,013 1,397,368

Phenotypes of a mutant

essential PubMed

a mgtE mutant has a growth defect on rich media, this can be suppressed by the addition of 25 mM Mg²⁺, moreover the mutant grows well on minimal medium in the presence of citrate (due to the activity of CitM) PubMed

a mgtE yfjQ mutant does not grow on rich media, this can be suppressed by the addition of 25 mM Mg²⁺, moreover the mutant grows well on minimal medium in the presence of citrate (due to the activity of CitM) PubMed

The protein

Protein family

SLC41A transporter family (single member, according to UniProt)

Domains

2 CBS domains (140-203, 204-260)

Effectors of protein activity

binds c-di-AMP PubMed

Structure

2YVX (from Thermus thermophilus, 34% identity) PubMed

2QBZ (the mgtE riboswitch)

Localization

cell membrane (according to UniProt)