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purC [Mon May 16 2016 15:54:16 GMT+0200 (CEST)]
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purC [Mon May 16 2016 15:54:16 GMT+0200 (CEST)]

phosphoribosylaminoimidazole succinocarboxamide synthase
locus
BSU06450
pI
4.00
mw
27.00 kDa
function
purine biosynthesis
product
phosphoribosylaminoimidazole
succinocarboxamide synthase
essential
no
ec
6.3.2.6
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of nucleotides], [SW|most abundant proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|G-box], [SW|PurR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    701,601 -> 702,326

    The protein

    Catalyzed reaction/ biological activity

  • ATP 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate L-aspartate = ADP phosphate (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (according to Swiss-Prot)

    • Protein family

  • SAICAR synthetase family (according to Swiss-Prot)

    • Structure

  • [PDB|1KUT] (from ''Thermotoga maritima'', 40% identity, 57% similarity) [Pubmed|16582479]

    • Expression and Regulation

    Operon

  • ''[protein|search|purE]-[protein|search|purK]-[protein|search|purB]-[protein|search|purC]-[protein|search|purS]-[protein|search|purQ]-[protein|search|purL]-[protein|search|purF]-[protein|search|purM]-[protein|search|purN]-[protein|search|purH]-[protein|search|purD]'' [Pubmed|3036807]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|3036807]

    • Regulation

  • repressed in the presence of purine nucleotides ([protein|search|PurR]) [Pubmed|7638212]
  • repressed in the presence of adenine or adenosine([protein|search|PurR]) [Pubmed|2536750]
  • repressed in the presence of guanine([protein|search|G-box]) [Pubmed|3036807]

    • Regulatory mechanism

  • [PurR]]: transcription repression [Pubmed|7638212]
  • [protein|search|PurR]: transcription repression (molecular inducer: PRPP) [Pubmed|2536750]
  • [protein|search|G-box]: transcription termination/ antitermination ([SW|riboswitch]) [http://www.ncbi.nlm.nih.gov/sites/entrez/3036807 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/12787499 PubMed2]

    • Additional information

  • the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]
  • belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]

    • References

  • 12884008,3036807,12923093,7638212,15378759