yxdM

ABC transporter (permease)

Locus: BSU_39630

Isoelectric point: 9.27

Molecular weight: 70.35 kDa

Protein length: 622 aa

Gene length: 1869 bp

Function: export of toxic peptides

Product: ABC transporter (permease)

Essential: no

Synonyms

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Transporters → ABC transporters → Exporters → Export of peptides
• Lifestyles → Coping with stress → Resistance against toxins/ antibiotics
• Groups of genes → Membrane proteins

Gene

Coordinates: 4,068,550 4,070,418

The protein

Protein family

• ABC-4 integral membrane protein family (according to UniProt)

Paralogous protein(s)

• PsdB

Localization

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• Genes: yxdL-yxdM-yxeA
  Description: PubMed

  Regulatory mechanism

  • YxdJ: activation, PubMed, in YxdJ regulon

  Regulation

  • induced by a cationic antimicrobial peptide, LL-37 (YxdJ) [Pubmed| 21078927]

Biological materials

Mutant

• MGNA-B705 (yxdM::erm), available at the NBRP B. subtilis, Japan
• BKE39630 (yxdM::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_GGCCCTTTTGTTTCTCGTGA, downstream forward: _UP4_ATGAACAAGTAAGGGGAGTG
• BKK39630 (yxdM::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_GGCCCTTTTGTTTCTCGTGA, downstream forward: _UP4_ATGAACAAGTAAGGGGAGTG

References

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