glucomannan-specific phosphotransferase system, EIIA component of the PTS
function
glucomannan uptake and phosphorylation
product
glucomannan-specific phosphotransferase system, EIIA component
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.2|Phosphotransferase system] → [category|SW 1.2.2.2|Sugar specific PTS proteins][category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.25|Utilization of glucomannan][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue][SW|Categories] containing this gene/protein
[SW|phosphotransferase systems], [SW|utilization of specific carbon sources], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|AbrB regulon], [SW|CcpA regulon], [SW|GmuR regulon]Gene
Coordinates on the chromosome (coding sequence)
626,933 -> 627,265
The protein
Protein family
[SW|PTS] permease, lactose permease (Lac) family [Pubmed|10627040]Structure
[PDB|3K1S] (IIA(Cel) from ''B. anthracis'', 42% identity)[SW|Interactions]
[protein|search|GmuA]-[PtsH|search|HPr], [protein|search|GmuA]-[protein|search|GmuB]Expression and Regulation
Operon
''[protein|search|gmuB]-[protein|search|gmuA]-[protein|search|gmuC]-[protein|search|gmuD]-[protein|search|gmuR]-[protein|search|gmuE]-[protein|search|gmuF]-[protein|search|gmuG]'' [Pubmed|18177310][SW|Sigma factor]
[protein|search|SigA] [Pubmed|18177310]Regulation
induced by conjac glucomannan (requires [protein|search|GmuG]) ([protein|search|GmuR]) [Pubmed|18177310]induced by cellobiose ([protein|search|GmuR]) [Pubmed|18177310]subject to carbon catabolite repression ([protein|search|CcpA]) [Pubmed|18177310]Regulatory mechanism
[protein|search|GmuR]: transcription repression [Pubmed|18177310][protein|search|CcpA]: transcription repression [Pubmed|18177310][protein|search|AbrB]: transcription activation [Pubmed|20817675]References
18177310,10627040,18177310,20817675 
