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MntR
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manganese!
nusG
transcription antitermination and pausing factor
product
sequence-specific RNA polymerase pause factor
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.1|Transcription] → [category|SW 3.2.1.3|Transcription elongation/ termination]Gene
Coordinates
117,890 118,423
The protein
Catalyzed reaction/ biological activity
binds to the non-template DNA within the paused transcription bubble [Pubmed|26742846]shifts [SW|RNA polymerase] to the posttranslocation register and induces pausing at 1,600 sites containing a consensus TTNTTT motif in the nontemplate DNA strand within the paused transcription bubble [pubmed|32817529][SW|Domains]
KOW domain (aa 128-156) (according to UniProt)Structure
[PDB|2JVV] (from ''E. coli'', 44% identity) [Pubmed|19500594][SW|Localization]
cytoplasm (according to UniProt)Biological materials
Mutant
GP2633 ([gene|43CFA3477B4EEB4CE0B2DF63ED2B5EDB171E79C7|nusG]::''cat''), available in [SW|Jörg Stülke]'s labBKE01010 ([gene|43CFA3477B4EEB4CE0B2DF63ED2B5EDB171E79C7|nusG]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE01010 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTATTCAGGACTGTCC, downstream forward: _UP4_TAATGTGAAAAAACTTGAAABKK01010 ([gene|43CFA3477B4EEB4CE0B2DF63ED2B5EDB171E79C7|nusG]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK01010 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTATTCAGGACTGTCC, downstream forward: _UP4_TAATGTGAAAAAACTTGAAAReferences
Reviews
Original publications
18852477,16707701,11101662,10027981,23033921,21040729,20384694,26742846,19500594,29887376,31719185,32817529 
