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zwf [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]
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zwf [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

glucose 6-phosphate dehydrogenase, pentose-phosphate pathway
Locus
BSU23850
Isoelectric point
5.28
Molecular weight
55.00 kDa
Function
initiation of the pentose phosphate pathway
Product
glucose 6-phosphate dehydrogenase
Essential
no
E.C.
1.1.1.49
Synonyms
yqjJ
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Carbon metabolism → Carbon core metabolism → Pentose phosphate pathway

    • Categories containing this gene/protein

  • carbon core metabolism

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,479,156 -> 2,480,625

    The protein

    Catalyzed reaction/ biological activity

  • D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH (according to Swiss-Prot)

    • Protein family

  • glucose-6-phosphate dehydrogenase family (according to Swiss-Prot)

    • Cofactors

  • Mg2+, Mn2+, Ca2+

    • Effectors of protein activity

  • NAD+, NADP+ and NADPH affect the enzyme kinetic PubMed

    • Structure

  • 1DPG (from Leuconostoc Mesenteroides, 45% identity, 62% similarity) PubMed

    • Additional information

  • The enzyme is a dimer PubMed

    • Expression and Regulation

    Operon

  • zwf PubMed

    • Regulation

  • constitutive PubMed

    • Biological materials

    Mutant

  • SM-NB3 (zwf-spc), available in Anne Galinier's and Boris Görke's labs

    • FLAG-tag construct

  • GP1401 (spc, based on pGP1331), available in the Stülke lab

    • Antibody

  • **

    • References

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