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fabG [2017-05-17 11:50:31]
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fabG [2017-05-17 11:50:31]

beta-ketoacyl-acyl carrier protein reductase
Locus
BSU15910
Isoelectric point
8.09
Molecular weight
26.13 kDa
Protein length
246 aa Sequence Blast
Gene length
738 bp Sequence Blast
Function
fatty acid biosynthesis
Product
beta-ketoacyl-acyl carrier protein reductase
Essential
yes
E.C.
1.1.1.100
Synonyms
ylpF

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
1,664,513 → 1,665,253

Phenotypes of a mutant

  • essential PubMed
  • The protein

    Catalyzed reaction/ biological activity

  • (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH (according to Swiss-Prot)
  • Protein family

  • short-chain dehydrogenases/reductases (SDR) family (according to Swiss-Prot)
  • Paralogous protein(s)

    Structure

  • 1I01 (the enzyme from E. coli) PubMed
  • Expression and Regulation

    Operons

    Description

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • Regulatory mechanism

  • FapR: repression, PubMed, in FapR regulon
  • ComA: activation, (ComA) PubMed, in ComA regulon
  • Regulation

  • FapR: repressed in the absence of malonyl-CoA or malonyl-ACP (FapR) PubMed
  • expression of the operon is strongly reduced during biofilm formation PubMed
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    References

    Reviews

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    Original Publications

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