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mprF [Sat Jan 07 2017 18:47:13 GMT+0100 (CET)]
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mprF [Sat Jan 07 2017 18:47:13 GMT+0100 (CET)]

synthesis of lysylphosphatidylglycerol (L-PG), lysinylation of phosphatidylglycerol provides some resistance against positively charged antimicrobial peptides
locus
BSU08425
pI
9.00
mw
96.00 kDa
function
lysyl-phosphatidylglycerol lipid biosynthesis
product
lysyl-phosphatidylglycerol synthase
essential
no
synonyms
yfiW, yfiX
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.2|Biosynthesis of phospholipids]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of lipids], [SW|membrane proteins]

    • Gene

    Coordinates on the chromosome (coding sequence)
    916,778 -> 919,348

    Phenotypes of a mutant

  • reduced conjugation of ICEBs1 [Pubmed|25069588,26833415]

    • The protein

    Structure

  • [PDB|4V36] (Lys-tRNA(Lys)-dependent lysyl-phosphatidylglycerol synthase domain from ''B. licheniformis'', 76% identity) [Pubmed|26261323]

    • [SW|Localization]

  • cell membrane at the septum [Pubmed|15743965]

    • Expression and Regulation

    Operon

  • ''mprF'' (according to [http://dbtbs.hgc.jp/COG/prom/yfiWX.html DBTBS])

    • Biological materials

    Mutant

  • MGNA-C310 (yfiX::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2308 NBRP B. subtilis, Japan]
  • GP2246 (''[protein|search|mprF]''::''ermC''), available in [SW|Jörg Stülke]'s lab

    • References

  • 19164152,18820022,19734140,18305156,12427923,15743965,25069588,26261323,26833415