2,3-diketo-5-methylthiopentyl-1-phosphate enolase, Rubisco-like protein
function
methionine salvage
product
2,3-diketo-5-methylthiopentyl-1-phosphate enolase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.10|Biosynthesis/ acquisition of methionine/ S-adenosylmethionine][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids]This gene is a member of the following [SW|regulons]
[SW|S-box]The protein
Catalyzed reaction/ biological activity
5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate (according to Swiss-Prot)Protein family
Type IV subfamily (according to Swiss-Prot)Structure
[PDB|2ZVI] [Pubmed|19690372]Expression and Regulation
Operon
''[protein|search|mtnW]-[protein|search|mtnX]-[protein|search|mtnB]-[protein|search|mtnD]'' [Pubmed|12022921][SW|Sigma factor]
[protein|search|SigA] [Pubmed|12022921]Regulation
repressed by casamino acids [Pubmed|12107147]induced by methionine starvation ([protein|search|S-box]) [Pubmed|10094622]Regulatory mechanism
[protein|search|S-box]: transcription termination/ antitermination, the [protein|search|S-box] [SW|riboswitch] binds S-adenosylmethionine resulting in termination [Pubmed|10094622]References
10094622,19279009,12022921,14551435,11914366,12107147,19194007,15102328,19690372,12787499,18039762 
