function
histidine uptake
product
histidine permease
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.1|Amino acid transporters] → [category|SW 1.2.4.1.4|APC superfamily][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.14|Biosynthesis/ acquisition of histidine][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.5|Utilization of histidine][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|transporters/ other], [SW|biosynthesis/ acquisition of amino acids], [SW|utilization of amino acids], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|CodY regulon], [SW|HutP regulon]Gene
Coordinates on the chromosome (coding sequence)
4,047,538 -> 4,048,965
The protein
Paralogous protein(s)
[protein|search|AapA], [protein|search|GabP], [protein|search|RocC], [protein|search|RocE], [protein|search|YbgF], [protein|search|YbxG], [protein|search|YdgF], [protein|search|YtnA], [protein|search|YvbW][SW|Localization]
cell membrane (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|hutP]-[protein|search|hutH]-[protein|search|hutU]-[protein|search|hutI]-[protein|search|hutG]-[protein|search|hutM]'' [Pubmed|10746760][SW|Sigma factor]
[protein|search|SigA] [Pubmed|8071225]Regulation
repressed by glucose ([protein|search|CcpA]) [Pubmed|8071225]induced by histidine ([protein|search|HutP]) [Pubmed|8071225]repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|8682780]Regulatory mechanism
[protein|search|CcpA]: transcription repression [Pubmed|8071225][protein|search|CodY]: transcription repression [Pubmed|8682780][protein|search|HutP]: transcriptional antitermination at a protein-dependent [SW|RNA switch] located between ''[protein|search|hutP]'' and ''[protein|search|hutH]'' [Pubmed|8071225]References
Reviews
Original publications
10746760,8071225,8682780,10217782 
