pbuG [Mon Aug 31 2015 13:52:53 GMT+0200 (CEST)]

hypoxanthin/ guanine permease

locus: BSU06370

pI: 8.81

mw: 46.00 kDa

function: hypoxanthine and guanine uptake

product: hypoxanthin/ guanine permease

essential: no

synonyms: yebB

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.6|Nucleotide/ nucleoside transporter]
• [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

syns: yebB

[SW|Categories] containing this gene/protein

• [SW|transporters/ other], [SW|biosynthesis/ acquisition of nucleotides], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|G-box], [SW|PurR regulon]

The protein

Paralogous protein(s)

• [protein|search|PbuO]

Structure

• [PDB|2EEW] (the pbuG riboswitch, U47c mutant, bound to hypoxanthine)

[SW|Localization]

• membrane [Pubmed|18763711]

Expression and Regulation

Operon

• ''pbuG'' [Pubmed|12923093]

Regulation

• repressed by hypoxanthine and guanine, [protein|search|PurR]-independent, ([protein|search|G-box])[Pubmed|12923093]
• repressed in the presence of adenine or adenosine([protein|search|PurR]) [Pubmed|2536750]

Regulatory mechanism

• [protein|search|PurR]: transcription repression (molecular inducer: PRPP) [Pubmed|2536750]
• [protein|search|G-box]: transcription termination/ antitermination ([SW|riboswitch]) [Pubmed|12923093]

References

• 11591660,12923093,11591660,18763711,12923093,12787499