hypoxanthin/ guanine permease
function
hypoxanthine and guanine uptake
product
hypoxanthin/ guanine permease
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.6|Nucleotide/ nucleoside transporter][category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|transporters/ other], [SW|biosynthesis/ acquisition of nucleotides], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|G-box], [SW|PurR regulon]The protein
Paralogous protein(s)
[protein|search|PbuO]Structure
[PDB|2EEW] (the pbuG riboswitch, U47c mutant, bound to hypoxanthine)[SW|Localization]
membrane [Pubmed|18763711]Expression and Regulation
Operon
''pbuG'' [Pubmed|12923093]Regulation
repressed by hypoxanthine and guanine, [protein|search|PurR]-independent, ([protein|search|G-box])[Pubmed|12923093]repressed in the presence of adenine or adenosine([protein|search|PurR]) [Pubmed|2536750]Regulatory mechanism
[protein|search|PurR]: transcription repression (molecular inducer: PRPP) [Pubmed|2536750][protein|search|G-box]: transcription termination/ antitermination ([SW|riboswitch]) [Pubmed|12923093]References
11591660,12923093,11591660,18763711,12923093,12787499