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degQ [Thu Dec 08 2016 16:28:39 GMT+0100 (CET)]
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degQ [Thu Dec 08 2016 16:28:39 GMT+0100 (CET)]

stimulates production of degradative enzymes and of extracellular poly-gamma-glutamate http://www.ncbi.nlm.nih.gov/sites/entrez/16091050 PubMed, stimulates phosphorylation of DegU by DegS http://www.ncbi.nlm.nih.gov/sites/entrez/17850253 PubMed, gene is not expressed in the lab strain 168 due to promoter down mutation in the -10 region (T - 10 ---> C) http://www.ncbi.nlm.nih.gov/sites/entrez/16091050 PubMed
locus
BSU31720
pI
6.00
mw
5.00 kDa
function
regulation of exoenzyme synthesis
product
pleiotropic regulator
essential
no
synonyms
sacQ
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.3|Control of response regulators/ other]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW 4.1.2.4|Regulation]

    • [SW|Categories] containing this gene/protein

  • [SW|biofilm formation], [SW|transcription factors and their control], [SW|sporulation proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|ComA regulon], [SW|DegU regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,257,092 -> 3,257,232

    Phenotypes of a mutant

  • loss of poly-gamma-glutamate production [Pubmed|16091050], no synthesis of nonribosomal peptides iturin A and plipastatin [http://www.ncbi.nlm.nih.gov/sites/entrez/16251307 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/10471562 PubMed2], reduced synthesis of degradative enzymes [Pubmed|3098732], increased genetic competence [Pubmed|3098732]

    • The protein

    Catalyzed reaction/ biological activity

  • stimulates autophosphorylation of [protein|search|DegS] [Pubmed|21965392]

    • Protein family

  • degQ family (according to Swiss-Prot)

    • [SW|Interactions]

  • [protein|search|DegQ]-[protein|search|DegS] [Pubmed|21965392]

    • Expression and Regulation

    Operon

  • ''[protein|search|degQ]'' [Pubmed|3007431]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|3007431]

    • Regulation

  • induced by high cell density ([protein|search|ComA]) [Pubmed|1901055]
  • subject to carbon catabolite repression [Pubmed|1901055]
  • controlled by [protein|search|DegU] [Pubmed|1901055]

    • Regulatory mechanism

  • [protein|search|ComA]: transcription activation [Pubmed|1901055]
  • [protein|search|DegU]: transcription activation [Pubmed|1901055]

    • Additional information

  • the gene is not expressed in the lab strain 168 due to promoter down mutation in the -10 region (T - 10 ---> C) [http://www.ncbi.nlm.nih.gov/sites/entrez/16091050 PubMed]

    • Biological materials

    Mutant

  • QB4851 (cat), available in the [SW|Stülke] lab

    • References

  • 17850253,2428811,19447339,3007431,1901055,16091050,21278284,21965392,26302846,27920766