cell shape-determining protein, forms filaments, the polymers control/restrict the mobility of the cell wall elongation enzyme complex, required for LytE activity
function
cell shape determation
product
cell shape-determining protein
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.2|Cell shape][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.4|Heat shock proteins][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|cell shape], [SW|heat shock proteins], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|SigI regulon], [SW|WalR regulon]Gene
Coordinates on the chromosome (coding sequence)
1,516,574 -> 1,517,581
The protein
Catalyzed reaction/ biological activity
forms ring-shaped filaments in a heterologous system [Pubmed|21091501]required for the activity of [protein|search|LytE] [Pubmed|23869552,16950129]Protein family
ftsA/mreB family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|MreB], [protein|search|Mbl][SW|Localization]
during logarithmic growth, [SW|MreBH] forms discrete patches thst move processively along peripheral tracks perpendicular to the cell axis [Pubmed|21636744]forms transverse bands as cells enter the stationary phase [Pubmed|21636744]close to the inner surface of the cytoplasmic membrane [Pubmed|16950129]reports on helical structures formed by MreBH [Pubmed|16950129,20566861] seem to be misinterpretation of data [Pubmed|21636744]normal localization depends on the presence of glucolipids, [protein|search|MreB] forms irregular clusters in an ''[protein|search|ugtP]'' mutant [Pubmed|22362028][SW|Interactions]
part of the [SW|cell wall biosynthetic complex] [Pubmed|21636744,21636745][SW|MreBH]-[protein|search|LytE] [Pubmed|16950129][SW|MreBH]-[protein|search|Mbl] [Pubmed|21636744][protein|search|MreB]-[SW|MreBH] [Pubmed|17064365][protein|search|RodZ]-[SW|MreBH] [Pubmed|23879732]Expression and Regulation
[SW|Sigma factor]
[protein|search|SigI] [Pubmed|18156261]Regulation
expression is increased in an ''[protein|search|ugtP]'' mutant [Pubmed|22362028]induced at high temperature ([protein|search|SigI], [protein|search|WalR]) [Pubmed|24125693,18156261]Regulatory mechanism
[protein|search|WalR]: transcription activation [Pubmed|24125693]References
Localization
17064365,20566861,21636744,21636745,22362028 Other original publications
16950129,19643765,16950129,18156261,19659933,21091501,22069484,23879732,23869552,24125693 
