pyrH [Mon Aug 31 2015 13:54:21 GMT+0200 (CEST)]

uridylate kinase

locus: BSU16510

pI: 5.00

mw: 25.00 kDa

function: pyrimidine biosynthesis

product: uridylate kinase

essential: no

ec: 2.7.4.22

synonyms: smbA

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of nucleotides]

This gene is a member of the following [SW|regulons]

• [SW|stringent response]

Gene

Coordinates on the chromosome (coding sequence): 1,719,802 -> 1,720,524

The protein

Catalyzed reaction/ biological activity

• ATP UMP = ADP UDP (according to Swiss-Prot)

Protein family

• UMP kinase family (according to Swiss-Prot)

Structure

• [PDB|2JJX] (from ''Bacillus anthracis'', 42% identity, 64% similarity) [Pubmed|18625239]

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Regulation

• [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]

References

• 12869195,8206849,1709162