sdpI

immunity protein, protection against SdpC

locus: BSU_33780

pI: 9.61

mw: 23.15 kDa

protein length: 207 aa

gene length: 624 bp

function: protection against SdpC

product: immunity protein

essential: no

synonyms: yvaZ

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 3,466,434 3,467,057

The protein

Paralogous protein(s)

• [protein|2B7F65B145005A8ADD2A278E3EA5A52DF162C837|YfhL], [protein|2E0FBCA66FB88EDFD345FA289F776C7CA23976F5|YbgB]

Effectors of protein activity

• in the presence of extracellular [protein|820635420B3980B620F3E3D7ACF7EDE9DC6275AD|SdpC], [protein|3FB5839A7A80CF52E627FF1744E50490F5CC390F|SdpI] binds and sequesters [protein|29A3EC8FB0C763A973273AA14EAEB904847C3002|SdpR] , this results in induction of the ''[gene|29A3EC8FB0C763A973273AA14EAEB904847C3002|sdpR]-[gene|3FB5839A7A80CF52E627FF1744E50490F5CC390F|sdpI]'' operon [Pubmed|16469701]

[SW|Localization]

• membrane (according to UniProt)

Expression and Regulation

Operons

• genes: [gene|29A3EC8FB0C763A973273AA14EAEB904847C3002|sdpR]-[gene|3FB5839A7A80CF52E627FF1744E50490F5CC390F|sdpI]
  description: [Pubmed|12817086]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|16469701], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB]: repression, [Pubmed|16469701], in [regulon|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB regulon]
  • [protein|29A3EC8FB0C763A973273AA14EAEB904847C3002|SdpR]: repression, [Pubmed|16469701], in [regulon|29A3EC8FB0C763A973273AA14EAEB904847C3002|SdpR regulon]

  regulation

  • induced by extracellular [protein|search|SdpC] ([protein|search|SdpR]) [Pubmed|16469701]

Biological materials

Mutant

• MGNA-A454 (yvaZ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/454 NBRP B. subtilis, Japan]
• BKE33780 ([gene|3FB5839A7A80CF52E627FF1744E50490F5CC390F|sdpI]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE33780 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AATTATGGAAATTATATTTT, downstream forward: _UP4_TGAAAAAGTGTCTTGCGGAG
• BKK33780 ([gene|3FB5839A7A80CF52E627FF1744E50490F5CC390F|sdpI]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK33780 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AATTATGGAAATTATATTTT, downstream forward: _UP4_TGAAAAAGTGTCTTGCGGAG

References

Reviews

• 20955377

Original Publications

• 12817086,16469701,20563570