valS [2017-05-31 13:58:36]

valyl-tRNA synthetase

locus: BSU28090

pI: 4.87

mw: 101.55 kDa

protein length: 880 aa

gene length: 2640 bp

function: translation

product: valyl-tRNA synthetase

essential: yes

ec: 6.1.1.9

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
• [category|SW 6|Groups of genes] → [category|SW 6.11|Efp-dependent proteins]

Gene

Coordinates: 2,866,664 → 2,869,306

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val) (according to Swiss-Prot)

Protein family

• ValS type 1 subfamily (according to Swiss-Prot)

Structure

• [PDB|1IYW] (from ''Thermus thermophilus'', 41% identity, 60% similarity) [Pubmed|12554880]

additional information

• belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]

Expression and Regulation

Operons

• genes: [gene|3E84B3AC08D0B314286CEF38534BD81B568F3E0E|valS]-[gene|80502F76F076C08CCE702F25095C06D14CD8154A|folC]
  description: [Pubmed|9098041]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|9098041], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [regulon|T-box|T-box]: transcription termination/antitermination, via [SW|riboswitch], in [regulon|T-box|T-box]

  regulation

  • induced by valine limitation ([SW|T-box]) [Pubmed|9098041,19258532]
  • the [SW|T-box] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]

References

Reviews

• 19258532

Original Publications

• 9098041,15378759,25310979