threonyl-tRNA synthetase (major)
product
threonyl-tRNA synthetase (major)
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases][SW|Categories] containing this gene/protein
[SW|translation], [SW|most abundant proteins]This gene is a member of the following [SW|regulons]
[SW|T-box]Gene
Coordinates on the chromosome (coding sequence)
2,959,257 -> 2,961,188
The protein
Catalyzed reaction/ biological activity
ATP L-threonine tRNA(Thr) = AMP diphosphate L-threonyl-tRNA(Thr) (according to Swiss-Prot) Protein family
class-II aminoacyl-tRNA synthetase family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|ThrZ], one of the two proteins has to be present for viability [Pubmed|17114254]Modification
Cys573 is S-bacillithiolated by NaOCl stress [Pubmed|22938038]Structure
[PDB|1TJE] (from ''Escherichia coli'', 44% identity, 63% similarity) [Pubmed|15525511]Additional information
subject to Clp-dependent proteolysis upon glucose starvation [Pubmed|17981983]Expression and Regulation
Operon
''[protein|search|thrS]'' [Pubmed|8969504][SW|Sigma factor]
[protein|search|SigA] [Pubmed|8288542]Regulation
induced by threonine limitation ([protein|search|T-box]) [Pubmed|19258532,8288542]expression transiently increases in the forespore [Pubmed|22848659]Regulatory mechanism
[protein|search|T-box]: [SW|RNA switch], transcriptional antitermination [Pubmed|19258532]Additional information
subject to Clp-dependent proteolysis upon glucose starvation [Pubmed|17981983]belongs to the 100 [[most abundant proteins]] [PubMed|15378759]the attenuator ([protein|search|T-box]) is inhibited by [protein|search|NusA] [ http://www.nature.com/articles/nmicrobiol20157 Reference]References
22938038,8288542,1379177,19258532,7476165,12136084,8969504,17114254,22848659,15378759 
