RNA polymerase ECF-type sigma factor SigW, required for the adaptation to membrane active agents, activated by alkaline shock and by polymyxin B, vancomycin, cephalosporin C, D-cycloserine, and triton X-100
function
adaptation to membrane-active compounds
product
RNA polymerase ECF-type sigma factor SigW
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.1|Transcription] → [category|SW 3.2.1.2|Sigma factors][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.1|Sigma factors][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)][SW|Categories] containing this gene/protein
[SW|transcription], [SW|sigma factors and their control], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)]This gene is a member of the following [SW|regulons]
[SW|AbrB regulon], [SW|SigW regulon]Gene
Coordinates on the chromosome (coding sequence)
194,849 -> 195,412
Phenotypes of a mutant
sensitive to ß-lactam antibiotics such as cefuroxime and to fosfomycin [Pubmed|22178969]Inactivation of ''[protein|search|alsR]'', ''[protein|search|sigD]'' and ''[protein|search|sigW]'' increases competitive fitness of ''Bacillus subtilis'' under non-sporulating conditions [Pubmed|22344650]The protein
Protein family
ECF subfamily (according to Swiss-Prot)Effectors of protein activity
[protein|search|RsiW] acts as antagonist of SigW (anti-SigW)[SW|Interactions]
[protein|search|RsiW]-[protein|search|SigW] [Pubmed|14993308][protein|search|SigW]-[protein|search|RpoB]-[protein|search|RpoC]Expression and Regulation
Operon
''[protein|search|sigW]-[protein|search|rsiW]'' [Pubmed|12207695][SW|Sigma factor]
[protein|search|SigW] [Pubmed|12207695]Regulation
induced under conditions of alkali shock or in the presence of the toxin [protein|search|SdpC] ([protein|search|SigW]) [Pubmed|12207695]repressed during logrithmic growth ([protein|search|AbrB]) [Pubmed|12076816]Regulatory mechanism
[protein|search|AbrB]: transcription repression [Pubmed|12076816]Biological materials
Mutant
1A905 ( ''sigW''::''erm''), [Pubmed|11244082], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A905&Search=1A905 BGSC]Labs working on this gene/protein
[SW|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage][SW|Thomas Wiegert], University of Bayreuth, Germany [http://www.genetik.uni-bayreuth.de/LSGenetik1/Thomas Wiegert-Dateien/Thomas Wiegert.html Homepage]References
Reviews
22381678,24921931,26901131,27344142 The [SW|SigW regulon]
9683469,16629676,17675383,11866510,9987136,10960106,23934352,23155385 Other original publications
11222589,14993308,16816000,17338440,12207695,11454200,14563871,12076816,19820159,21821766,22344650,14993308,23185515,20817771,21542858,22178969,27137497 
