polA [Tue Jul 12 2016 11:15:44 GMT+0200 (CEST)]

DNA polymerase I, required for repair of UV- or MMS-induced DNA damage

locus: BSU29090

pI: 4.00

mw: 98.00 kDa

function: DNA replication

product: DNA polymerase I

essential: no

ec: 2.7.7.7

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.1|DNA replication]
• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination]
• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins]

[SW|Categories] containing this gene/protein

• [SW|DNA repair/ recombination]

Gene

Coordinates on the chromosome (coding sequence): 2,973,182 -> 2,975,824

The protein

Catalyzed reaction/ biological activity

• has DNA polymerase and 5'-3' exonuclease activity, but no 3'-5' exonuclease activity [Pubmed|16045613]

Protein family

• DNA polymerase type-A family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|YpcP], one of the two proteins has to be present for viability [Pubmed|17114254]

Structure

• [PDB|1XWL] (large fragment, corresponds to AA 310 to 880, Geobacillus stearothermophilus)

[SW|Interactions]

• [protein|search|PolA]-[SW|PolY1]-[protein|search|DnaN] [Pubmed|16045613], [protein|search|PolA]-[SW|PolY2] [Pubmed|16045613]

References

• 17114254,16045613,17905985, 27399782